2016

Rao M, Okreglak V, Chio US, Cho H, Walter P, and Shan SO. (2016) eLife “Multiple selection filters ensure accurate tail-anchor membrane protein targeting” PMID: 27925580.

Chandrasekar S, Shan SO. (2016) J. Biol. Chem. “Anionic phospholipids and the Albino3 translocase activate SRP-receptor interaction during LHCP targeting.” PMID:27895124.

Chandrasekar S, Sweredoski MJ, Sohn CH, Hess S, Shan SO. (2016) J. Biol. Chem. “Co-evolution of two GTPases enables efficient protein targeting in an RNA-less chloroplast Signal Recognition Particle pathway.” PMID:27895118.

Shan SO. (2016) Trends Biochem. Sci. “ATPase and GTPase Tangos drive intracellular protein transport”. PMID: 27658684.

Liang FC, Kroon G, McAvoy CZ, Chi C, Wright P, and Shan SO. (2016) Proc. Natl. Acad. Sci. “Conformational dynamics of a membrane protein chaperone enables spatially-regulated substrate capture and release.” PMID: 26951662.

Chen Y, Shen K, Shan SO, and Kou SC. (2016) J. Amer. Statist. Assoc. accepted. “Analyzing single-molecule protein transportation experiments via hierarchical hidden Markov Models”.

2015

Gristick HB, Rome ME, Chartron J, Rao M, Hess S, Shan SO, and Clemons WM Jr. (2015) J. Biol. Chem. “Mechanism of assembly of a substrate transfer complex during tail-anchored protein targeting.” PMID: 26451041.

Ariosa AR, Lee JH, Wang S, Saraogi I, and Shan SO. (2015) Proc. Natl. Acad. Sci. "Regulation by a chaperone improves substrate selectivity during cotranslational protein targeting." PMID: 26056263.

von Loeffelholz O, Jiang Q (姜启阳), Ariosa AR, Karuppasamy M, Huard K, Berger I, Shan SO, and Schaffitzel C. (2015) Proc. Natl. Acad. Sci. "Ribosome–SRP–FtsY cotranslational targeting complex in the closed state." PMID: 25775537.

2014

Rome ME, Chio US, Rao M, Gristick HB, and Shan SO. (2014) Proc. Natl. Acad. Sci. "Differential gradients of interaction affinities drive efficient targeting and recycling in the GET pathway." PMID: 25368153.

Saraogi I, Akopian D, and Shan SO. (2014) J. Cell Biol. "Regulation of cargo recognition, commitment, and unloading drives cotranslational protein targeting." PMID: 24914238.

Zhang X and Shan SO. (2014) Annu. Rev. Biophysics "Fidelity of cotranslational protein targeting by the signal recognition particle." PMID: 24895856.

Guo H, Xiong Y, Witkowski P, Cui J, Wang LJ, Sun J, Lara-Lemus R, Haataja L, Hutchison K, Shan SO, Arvan P, and Liu M. (2014) J. Biol. Chem. "Inefficient Translocation of Preproinsulin Contributes to Pancreatic β Cell Failure and Late-onset Diabetes." PMID: 24770419.

Gristick HB, Rao M, Chartron JW, Rome ME, Shan SO, and Clemons WM Jr. (2014) Nat. Struct. Mol. Biol. "Crystal structure of ATP-bound Get3–Get4–Get5 complex reveals regulation of Get3 by Get4." PMID: 24211265.

Saraogi I and Shan SO. (2014) Biochim Biophys Acta. “Co-translational protein targeting to the bacterial membrane.” PMID: 24513458.

Loson OC, Liu R, Rome ME, Meng S, Kaiser JT, Shan SO, and Chan DC. (2014) Structure. “The mitochondrial fission receptor MiD51 requires ADP as a cofactor”. PMID: 24508339.

2013

Saraogi I and Shan SO. (2013) Biochim Biophys Acta. "Co-translational protein targeting to the bacterial membrane.” PMID: 24513458.

Voigts-Hoffmann F, Schmitz N, Shen K, Shan SO, Ataide SF, and Ban N. (2013) Molecular Cell "The Structural Basis of FtsY Recruitment and GTPase Activation by SRP RNA." PMID: 24727835.

Shen K, Wang Y, Hwang Fu YH, Zhang Q, Feigon J, and Shan SO. (2013) J. Biol. Chem. "Molecular mechanism of GTPase activation at the SRP RNA distal end." PMID: 24151069.

Rome ME, Rao M, Clemons WM Jr., and Shan SO. (2013) Proc. Natl. Acad. Sci. “Precise timing of ATPase activation drives targeting of tail-anchored proteins.” PMID: 23610396.

von Loeffelholz O, Knoops K, Ariosa AR, Zhang X, Karuppasamy M, Huard K, Schoehn G, Berger I, Shan SO, and Schaffitzel C. (2013) Nat. Struct. Mol. Biol. “Structural Basis of Signal Sequence Surveillance and Selection by the SRP-FtsY Complex.” PMID: 23563142.

Nguyen TX, Jaru-Ampornpan P, Lam VQ, Cao P, Piszkiewicz S, and Shan SO. (2013) J. Biol. Chem. “Mechanism of an ATP-independent protein disaggregase. I. Structure of a membrane protein aggregate reveals a mechanism of recognition by its chaperone.” PMID: 23525109.

Jaru-Ampornpan P, Liang FC, Nisthal A, Nguyen TX, Wang P, Shen K, Mayo SL, and Shan SO. (2013) J. Biol. Chem. “Mechanism of an ATP-independent protein disaggregase. II. Distinct molecular interactions drive multiple steps during aggregate disassembly.” PMID: 23519468.

Pierce NW, Lee JE, Liu X, Sweredoski MJ, Graham RLJ, Larimore EA, Rome ME, Zheng N, Clurman BE, Hess S, Shan SO, and Deshaies RJ. (2013) Cell 153 1-10. “Cand1 Promotes Assembly of New SCF Complexes through Dynamic Exchange of F Box Proteins.” PMID: 23453757.

Akopian D, Dalal K, Shen K, Duong F, and Shan SO. (2013) J. Cell Biol. 200 (4), 397-405. “SecYEG activates GTPases to drive the completion of cotranslational protein targeting.” PMID: 23401005.

Akopian D, Shen K, Zhang X, and Shan SO. (2013) Annu. Rev. Biochem. “Signal Recognition Particle: An Essential Protein Targeting Machine.” PMID: 23414305.

2012

Shen K, Arslan S, Akopian D, Ha T, and Shan SO. (2012) Nature 492 (7428):271-5. “Activated GTPase movement on an RNA scaffold drives cotranslational protein targeting.” PMID: 23235881.

Ariosa AR, Duncan S, Saraogi I, Lu X, Brown A, Phillips GJ, and Shan SO. (2012) Mol. Biol. Cell. “Fingerloop activates cargo delivery and unloading during co-translational protein targeting.” PMID: 23135999.

Liu M, Lara-Lemus R, Shan SO, Wright J, Haataja L, Barbetti F, Guo H, Larkin D, and Arvan P. (2012) Diabetes, 61: 828-837. “Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetes.” PMID: 22357960.

Zhang D and Shan SO. (2012) J. Biol. Chem. 287(10):7652-60, “Translation elongation regulates substrate selection by the Signal Recognition Particle.” PMID: 22228766.

Zhang D, Sweredoski MJ, Graham RL, Hess S, and Shan SO. (2012) Mol. Cell Proteomics, 11(2):M111.011585, “Novel proteomic tools reveal essential roles of SRP and importance of proper membrane protein biogenesis.” PMID: 22030350.

2011

Saraogi I, Akopian D, and Shan SO. (2011) Protein Sci. 20, 1790-1795. “A tale of two GTPases in co-translational protein targeting.” PMID: 21898651.

Saraogi I, Zhang D, Chandrasekar S, and Shan SO. (2011) J. Am. Chem. Soc. 133, 14936-9. "Site-specific fluorescent labeling of nascent proteins on the translating ribosome." PMID: 21870811.

Nguyen TX, Chandrasekar S, Neher S, Walter P, and Shan SO. (2011) Biochemistry 50 , 7208-7217. “Concerted complex assembly and GTPase activation in the chloroplast signal recognition particle.” PMID: 21780778.

Ataide SF, Schmitz N, Shen K, Ke A, Shan SO, Doudna JA, and Ban N. (2011) Science 331, 881-886. “The crystal structure of the signal recognition particle in complex with its receptor.” PMID: 21330537.

Shen K, Zhang X, and Shan SO. (2011) RNA 17, 892-902. “Synergistic actions between the SRP RNA and translating ribosome allow efficient delivery of the correct cargos during cotranslational protein targeting.” PMID: 21460239.

Saraogi I and Shan SO. (2011) Traffic 12, 535-542. “Molecular mechanism of co-translational protein targeting by the signal recognition particle.” PMID: 21291501.

Estrozi LF, Boehringer D, Shan SO, Ban N, and Schaffitzel C. (2011) Nat. Struct. Mol. Biol. 18, 88-90. "Cryo-EM structure of the E. coli translating ribosome in complex with SRP and its receptor.” PMID: 21151118.

Zhang X, Lam VQ, Mou Y, Kimura T, Chung J, Chandrasekar S, Winkler JR, Mayo SL, and Shan SO. (2011) Proc. Nat. Acad. Sci. 108, 6450-6455. “Direct visualization reveals dynamics of a transient intermediate during protein assembly.” PMID: 21464281.

2010

Lam VQ, Akopian D, Rome ME, Henningsen D, and Shan SO. (2010) J. Cell. Biol. 190, 623-635 “Lipid activation of the signal recognition particle receptor provides spatial coordination of protein targeting.” PMID: 20733058.

Zhang X, Rashid R, Wang K, and Shan SO. (2010) Science 328, 757-760. "Sequential checkpoints govern substrate selection during cotranslational protein targeting.” PMID: 20448185.

Jaru-Ampornpan P, Shen K, Lam VQ, Ali M, Doniach S, Jia TZ, and Shan SO. (2010) Nat. Struct. Mol. Biol. 17, 696-702. “ATP-independent reversal of a membrane protein aggregate by a chloroplast SRP subunit.” PMID: 20424608.

Shen K and Shan SO. (2010) Proc. Natl. Acad. Sci. 107, 7698-7703. “Transient tether between the SRP RNA and SRP receptor ensures efficient cargo delivery during cotranslational protein targeting.” PMID: 20385832.

2009

Pierce NW, Kleiger G, Shan SO, and Deshaies RJ. (2009) Nature 462, 615-619. “Detection of sequential polyubiquitylation on a millisecond timescale.” PMID: 19956254.

Jaru-Ampornpan P, Nguyen TX, and Shan SO. (2009) Mol. Biol. Cell 20, 3965-3973. A distinct mechanism to achieve efficient signal recognition particle (SRP)-SRP receptor interaction by the chloroplast SRP pathway.” PMID: 19587121.

Shan SO, Schmidt S, and Zhang X. (2009) Biochemistry 48, 6696-6704. “Signal recognition particle (SRP) and SRP receptor: a new paradigm for multistate regulatory GTPases.” PMID: 19469550.

Zhang X, Schaffitzel C, Ban N, and Shan SO. (2009) Proc. Natl. Acad. Sci. 106, 1754-1759. "Multiple conformational switches in a GTPase complex control co-translational protein targeting." PMID: 19174514.

2008

Zhang X, Kung S, and Shan SO. (2008) J. Mol. Biol 381, 581-593. "Demonstration of multistep mechanism for assembly of the SRP-SRP receptor complex: implications for the catalytic role of SRP RNA." PMID: 18617187.

Chandrasekar S, Chartron J, Jaru-Ampornpan P, and Shan SO. (2008) J. Mol. Biol. 375, 425-436. “Structure of the chloroplast signal recognition particle (SRP) receptor: domain arrangement modulates SRP-receptor interaction.” PMID: 18035371.

2007

Shan SO, Chandrasekar S, and Walter P. (2007) J. Cell Biol 178, 611-620. “Conformational Changes in the GTPase Modules of the Signal Recognition Particle and Its Receptor Drive Initiation of Protein Translocation.” PMID: 17682051. Highlighted in Faculty of 1000.

Jaru-Ampornpan P, Chandrasekar S, and Shan SO. (2007) Mol. Biol. Cell 18, 2636-2645. “Efficient Interaction between Two GTPases Allows the Chloroplast SRP Pathway to Bypass the Requirement for an SRP RNA." PMID: 17475780. Highlighted in InCyte from MBC.

2001-2006

Shan SO and Walter P. (2005) Biochemistry 44,6214-6222. “Molecular Crosstalk between the nucleotide specificity determinant of the SRP GTPase and the SRP Receptor”

Shan SO and Walter P. (2005) FEBS Letters 579, 921-926. “Co-translational rotein targeting by the signal recognition particle.”

Chu F, Shan SO, Moustakas DT, Alber F, Egea F, Stroud RM, Walter P, and Burlingame AL. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 16454-16459. “Unraveling the interface of signal recognition particle and its receptor by using chemical cross-linking and tandem mass-spectrometry.”

Shan SO, Stroud RM, and Walter P. (2004) PLoS Biology 2, e320. “Mechanism of Association and Activation between Two GTPases.”

Egea PF, Shan SO, Napetschnig J, Savage DF, Walter P, and Stroud RM. (2004) Nature 427, 215-221. “Substrate twinning activates the signal recognition particle and its receptor.” Highlighted in Faculty of 1000

Shan SO and Walter P. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 4480 – 4485. “Induced Nucleotide Specificity in a GTPase.”

Peluso P, Shan SO, Nock S, Herschlag D, and Walter P. (2001) Biochemistry 40 , 15224-15233. “Role of SRP RNA in the GTPase Cycles of Ffh and FtsY.” Highlighted in Faculty of 1000