Welcome to Shan Group

Our research interfaces between chemistry and biology to understand fundamental cellular processes at the level of chemical and physical principles.

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Our attention currently focuses on (1) a pair of GTPases in the signal recognition particle (SRP) and the SRP receptor (SR) that act as molecular switches to control the delivery of newly synthesized proteins to cellular membranes; (2) the molecular mechanism that drives the targeting of tail-anchored proteins by the GET pathway; (3) a novel chaperone found in the chloroplast SRP system that actively disrupts existing protein aggregates; and (4) how nascent proteins are selected into the correct biogenesis pathways.

SRP Pathway

SRP is a universally conserved protein targeting machinery that couples the synthesis of ~30% of cellular proteins to their membrane localization.

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Yeast GET Pathway

The Guided Entry of Tail-anchored protein (GET) pathway mediates the delivery of tail-anchored proteins to the ER.

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Novel Membrane Protein Chaperone

The biogenesis of membrane proteins poses enormous challenges to cellular protein homeostasis. Using the Light Harvesting Complex Protein (LHCP) family as model substrates, we discovered a novel chaperone, cpSRP43, that overcomes the aggregation and ensures the targeted delivery of LHCPs.

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Crowding at the Ribosome Exit Site

Accumulating data have showed that the ribosome exit site is a crowded environment where many factors rendezvous, including chaperones, modification enzymes, and protein targeting and translocation machineries.

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